TXNL1

Across TCGA patient cohorts, TXNL1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNL1-associated genes across cancer lineages are Caspase-7-cleavedD198, Annexin-1, and STAT3_pY705. Each is linked with TXNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNL1-to-partner and partner-to-TXNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TXNL1-low versus TXNL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNL1→partner) and Y-score (partner→TXNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.509	+2.019	.038	.017	3	2
UCEC	Annexin-1 →	+0.782	+3.604	<.001	.001	3	1
UCEC	STAT3_pY705 →	-0.326	-1.807	.002	.027	3	1
UCEC	Tuberin →	+0.286	+2.009	.010	.017	3	1
UCEC	ASNS →	+0.707	+2.700	<.001	.006	3	1
UCEC	eIF4E →	+0.215	+4.087	.013	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Caspase-7-cleavedD198 by TXNL1 expression — UCEC

Explore this box plot interactively →