TXNIP

Across TCGA pan-cancer cohorts, TXNIP Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TXNIP data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TXNIP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNIP expression acts as an unfavorable survival marker.

THYM, BLCA, and LUSC are the cancer types where TXNIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	All	0.123	0.871	<.001	12	view →
BLCA	OS	Median	IV	0.253	0.606	.016	6	view →
LUSC	OS	Median	All	0.164	0.762	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TXNIP–THYM (DFS)

Open the THYM breakdown →