TXNIP

Across TCGA pan-cancer cohorts, TXNIP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TXNIP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TXNIP RNA is repressed in tumor relative to normal tissue. In most cancer types TXNIP is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUSC are the cancer types where TXNIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.724	<.001	11	view →
THCA	Male	II,III,IV	−1.235	<.001	10	view →
LUSC	All	III,IV	−2.295	<.001	8	view →
LUAD	Female	III,IV	−1.193	<.001	8	view →
KICH	Male	II,III,IV	−2.346	<.001	7	view →
UCEC	All	All	−2.871	<.001	6	view →
BLCA	Male	III,IV	−2.679	.003	6	view →
BRCA	All	II,III,IV	−1.850	<.001	6	view →
STAD	All	All	−0.932	.007	4	view →
HNSC	Male	All	−0.954	.007	3	view →
CHOL	All	II,III,IV	+1.579	.032	2	view →
PRAD	All	All	−0.558	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TXNIP–COAD

Open the COAD breakdown →