TXNIP

Across TCGA pan-cancer cohorts, TXNIP mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TXNIP data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TXNIP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TXNIP expression acts as an unfavorable survival marker.

LUAD, LSCC, and PDAC are the cancer types where TXNIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.314	0.685	.007	25	view →
LSCC	DFS	Quartile	II,III,IV	0.620	0.933	.024	3	view →
PDAC	DFS	Tertile	All	0.325	0.485	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TXNIP–LUAD (DFS)

Open the LUAD breakdown →