TXNIP

Across TCGA patient cohorts, TXNIP protein abundance is significantly associated with the RNA expression of many other genes, with 8,190 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TXNIP-associated genes across cancer lineages are ARRDC4, TRIM22, and GIMAP8. Each is linked with TXNIP in more than 5 cancer types. Because this analysis shows association rather than direction, both TXNIP-to-partner and partner-to-TXNIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TXNIP versus ARRDC4 in HNSC, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNIP→partner) and Y-score (partner→TXNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARRDC4 →	+0.690	+0.366	.001	<.001	3	6
OV	TRIM22 →	+0.983	+0.448	.001	.008	3	5
OV	GIMAP8 →	+0.880	+0.607	<.001	<.001	3	5
BRCA	CTSW →	+0.927	+0.313	.001	.002	3	5
HNSC	GIMAP5 →	+0.525	+0.309	<.001	.001	3	5
OV	MIR27B →	+2.068	+0.801	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,190 associations by consensus.

TXNIP vs ARRDC4 — HNSC

Explore this scatter interactively →