TXNIP

Across TCGA patient cohorts, TXNIP mutation is significantly associated with the RNA expression of many other genes, with 2,251 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNIP-associated genes across cancer lineages are RNA5SP422, RNA5SP412, and RNU6-643P. Each is linked with TXNIP in more than 2 cancer types. Because this analysis shows association rather than direction, both TXNIP-to-partner and partner-to-TXNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP422 grouped by TXNIP-low versus TXNIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNIP→partner) and Y-score (partner→TXNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP422 →	+0.789	+2.211	<.001	.001	3	3
UCEC	RNA5SP412 →	+0.446	+2.189	.004	.002	3	3
BRCA	RNU6-643P →	+0.264	+7.470	<.001	<.001	3	2
STAD	RNU6-290P →	+0.596	+5.206	<.001	.001	3	2
STAD	RNA5SP23 →	+0.293	+4.678	<.001	.007	3	2
STAD	RNA5SP525 →	+0.388	+5.465	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,251 associations by consensus.

RNA5SP422 by TXNIP expression — UCEC

Explore this box plot interactively →