TXNIP

Across TCGA patient cohorts, TXNIP mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNIP-associated genes across cancer lineages are eIF4E, JNK2, and MEK1. Each is linked with TXNIP in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNIP-to-partner and partner-to-TXNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TXNIP-low versus TXNIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNIP→partner) and Y-score (partner→TXNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+3.321	.022	.010	3	1
UCEC	JNK2 →	+0.188	+1.807	.022	.027	3	1
UCEC	MEK1 →	+0.531	+3.906	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.156	-3.571	.011	.002	3	1
UCEC	Notch1 →	+0.282	+3.009	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.367	+2.331	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4E by TXNIP expression — UCEC

Explore this box plot interactively →