TXNIP

Across TCGA cell cohorts, TXNIP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,501 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TXNIP-associated GO terms across cancer lineages are Cellular response to tumor cell, Vesicle budding from membrane, and Cellular response to oxidised low-density lipoprotein particle stimulus. Each is linked with TXNIP in more than 18 cancer types. Because this analysis shows association rather than direction, both TXNIP-to-partner and partner-to-TXNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to tumor cell grouped by TXNIP-low versus TXNIP-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNIP→partner) and Y-score (partner→TXNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Cellular response to tumor cell →	+0.415	+4.439	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Vesicle budding from membrane →	+0.067	+4.181	.002	<.001	3	14
LUNG_NSCLC_LUAD	Cellular response to oxidised low-density lipoprotein particle stimulus →	+0.157	+2.668	<.001	<.001	3	12
OVARY	Response to tumor cell →	+0.195	+3.848	<.001	<.001	3	12
PANCREAS	Response to steroid hormone →	+0.085	+2.816	<.001	<.001	3	12
SOFT_TISSUE	Response to endoplasmic reticulum stress →	+0.050	+2.947	.002	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,501 associations by consensus.

Cellular response to tumor cell by TXNIP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →