TXNIP

Across TCGA cell cohorts, TXNIP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TXNIP-associated genes across cancer lineages are GZMK, TAFA1, and C16orf96. Each is linked with TXNIP in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNIP-to-partner and partner-to-TXNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by TXNIP-low versus TXNIP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNIP→partner) and Y-score (partner→TXNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GZMK →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.238	+3.103	.001	.004	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LARGE_INTESTINE	FCN1 →	+0.052	+2.925	<.001	.007	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	LCE3D →	+0.051	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GZMK by TXNIP expression — LARGE_INTESTINE

Explore this box plot interactively →