Across TCGA patient cohorts, TXNDC8 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC8-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK2, and Ku80. Each is linked with TXNDC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC8-to-partner and partner-to-TXNDC8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC8→partner) and Y-score (partner→TXNDC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.694	+2.321	.006	.035	3	1
UCEC	JNK2 →	+0.202	+2.321	.043	.035	3	1
UCEC	Ku80 →	+0.305	+3.472	.010	.002	3	1
UCEC	MEK1 →	+0.418	+3.000	.022	.036	3	1
UCEC	NDRG1_pT346 →	-0.544	-2.321	.027	.035	3	1
UCEC	p62 Lck ligand →	+0.528	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TXNDC8 survival (RNA) · tumor vs normal (RNA) · all TXNDC8 data types