Across TCGA pan-cancer cohorts, TXNDC8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TXNDC8’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where TXNDC8 RNA is repressed in tumor relative to normal tissue. In most cancer types TXNDC8 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.
KICH, KIRC, and KIRP are the cancer types where TXNDC8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXNDC8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.