TXNDC15

Across TCGA patient cohorts, TXNDC15 mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXNDC15-associated genes across cancer lineages are RNA5SP373, RN7SKP286, and SPATA31D4. Each is linked with TXNDC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC15-to-partner and partner-to-TXNDC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP373 grouped by TXNDC15-low versus TXNDC15-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC15→partner) and Y-score (partner→TXNDC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP373 →	+0.441	+7.333	<.001	<.001	3	2
UCEC	RN7SKP286 →	+0.054	+4.360	<.001	.004	3	2
SKCM	SPATA31D4 →	+0.011	+5.328	.002	.003	3	2
BLCA	SNORD116-18 →	+0.604	+5.497	<.001	.004	3	2
UCEC	IGKV1OR2-6 →	+0.729	+2.225	.008	.008	3	1
UCEC	MIR6075 →	+0.279	+2.638	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

RNA5SP373 by TXNDC15 expression — LUAD

Explore this box plot interactively →