TXNDC12

Across TCGA pan-cancer cohorts, TXNDC12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TXNDC12 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TXNDC12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TXNDC12 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where TXNDC12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.692	1.000	<.001	36	view →
LUAD	OS	Quartile	II,III,IV	0.712	1.000	.012	15	view →
PDAC	DFS	Quartile	II,III,IV	0.840	0.693	.012	12	view →
OV	DFS	Median	All	0.681	0.942	.016	8	view →
GBM	DFS	Quartile	All	0.623	0.905	.002	6	view →
HNSC	DFS	Tertile	All	0.904	0.685	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TXNDC12–CCRCC (OS)

Open the CCRCC breakdown →