TXNDC11

Across TCGA cell cohorts, TXNDC11 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TXNDC11-associated genes across cancer lineages are IQCF6, TAS2R40, and OR2AK2. Each is linked with TXNDC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TXNDC11-to-partner and partner-to-TXNDC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by TXNDC11-low versus TXNDC11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXNDC11→partner) and Y-score (partner→TXNDC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.132	+2.397	.002	.003	3	2
PANCREAS	TAS2R40 →	+0.026	+4.237	<.001	.006	3	1
OVARY	OR2AK2 →	+0.062	+4.029	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PROKR2 →	+0.066	+3.624	.003	.001	3	1
UPPER_AERODIGESTIVE_TRACT	RFPL3 →	+0.058	+3.954	.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	DEFA6 →	+0.049	+3.624	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

IQCF6 by TXNDC11 expression — LARGE_INTESTINE

Explore this box plot interactively →