TXN

Across TCGA pan-cancer cohorts, TXN mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TXN data layer compared with 25 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TXN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TXN expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and LUAD are the cancer types where TXN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.708	0.404	.008	10	view →
LSCC	OS	Median	II,III,IV	0.893	0.636	.027	7	view →
LUAD	DFS	Median	All	1.000	0.811	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TXN–GBM (OS)

Open the GBM breakdown →