TXLNGY

Across TCGA pan-cancer cohorts, TXLNGY RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TXLNGY’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TXLNGY RNA is repressed in tumor relative to normal tissue. In most cancer types TXLNGY is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and CHOL are the cancer types where TXLNGY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TXLNGY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−1.192	<.001	5	view →
KICH	Male	III,IV	−1.784	.001	4	view →
CHOL	Male	All	+1.926	.003	3	view →
LUSC	Male	All	−0.622	.003	2	view →
HNSC	Male	II,III,IV	−0.594	.022	2	view →
PRAD	All	All	+0.483	.001	2	view →
BLCA	Female	All	−0.006	.042	2	view →
LIHC	Male	All	+0.431	.009	1	view →
KIRC	Male	All	−0.244	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TXLNGY–KIRP

Open the KIRP breakdown →