TXLNB

Across TCGA patient cohorts, TXLNB mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TXLNB-associated genes across cancer lineages are Di-Ras3, 14-3-3_zeta, and Dvl3. Each is linked with TXLNB in more than 2 cancer types. Because this analysis shows association rather than direction, both TXLNB-to-partner and partner-to-TXLNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by TXLNB-low versus TXLNB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXLNB→partner) and Y-score (partner→TXLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.128	-1.986	.011	.029	3	3
LUSC	14-3-3_zeta →	+0.345	+3.045	.049	.018	3	2
LUSC	Dvl3 →	+0.281	+3.009	.005	.019	3	2
UCEC	eEF2 →	+0.297	+1.514	.014	.015	3	2
UCEC	EGFR_pY1068 →	-0.202	-1.807	.017	.004	3	2
UCEC	eIF4E →	+0.153	+2.335	.033	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Di-Ras3 by TXLNB expression — UCEC

Explore this box plot interactively →