TXLNB

Across TCGA cell cohorts, TXLNB mutation is significantly associated with the RNA expression of many other genes, with 378 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TXLNB-associated genes across cancer lineages are C1orf146, GML, and SMR3B. Each is linked with TXLNB in more than 2 cancer types. Because this analysis shows association rather than direction, both TXLNB-to-partner and partner-to-TXLNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by TXLNB-low versus TXLNB-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TXLNB→partner) and Y-score (partner→TXLNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1orf146 →	+0.015	+3.734	<.001	.006	3	3
BLOOD_Leukemia	GML →	+0.107	+4.152	<.001	.009	3	2
LUNG_NSCLC_LUAD	SMR3B →	+0.071	+3.947	.009	.004	3	2
LUNG_NSCLC_LUAD	SSX7 →	+0.011	+4.078	<.001	.009	3	2
LARGE_INTESTINE	PES1 →	+0.548	+2.800	.001	.001	3	1
LARGE_INTESTINE	EIF3L →	+0.430	+3.087	.009	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 378 associations by consensus.

C1orf146 by TXLNB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →