TWSG1

Across TCGA patient cohorts, TWSG1 mutation is significantly associated with the RNA expression of many other genes, with 1,632 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWSG1-associated genes across cancer lineages are RNU6-120P, TRDV3, and HAUS1P3. Each is linked with TWSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWSG1-to-partner and partner-to-TWSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-120P grouped by TWSG1-low versus TWSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWSG1→partner) and Y-score (partner→TWSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-120P →	+0.294	+3.249	<.001	.005	3	2
UCEC	TRDV3 →	+0.321	+2.357	<.001	.002	3	2
BLCA	HAUS1P3 →	+0.164	+5.147	<.001	.003	3	1
BLCA	FRG2DP →	+0.059	+4.788	<.001	.006	3	1
BLCA	MIR4634 →	+0.517	+4.497	<.001	.009	3	1
BLCA	NKAIN1P2 →	+0.059	+5.814	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,632 associations by consensus.

RNU6-120P by TWSG1 expression — UCEC

Explore this box plot interactively →