TWSG1

Across TCGA pan-cancer cohorts, TWSG1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TWSG1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TWSG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TWSG1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where TWSG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TWSG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.267	<.001	12	view →
KIRC	Male	II,III,IV	−1.038	<.001	11	view →
KICH	Female	II,III,IV	−1.641	<.001	7	view →
BRCA	All	II,III,IV	+0.465	<.001	6	view →
LIHC	Female	All	+0.441	.015	4	view →
THCA	All	All	−0.279	.021	4	view →
CHOL	All	All	+1.478	<.001	3	view →
LUSC	Male	All	+0.361	.020	3	view →
UCEC	All	All	−1.041	<.001	2	view →
PRAD	All	All	−0.521	<.001	2	view →
LUAD	Male	II,III,IV	+0.459	.034	2	view →
READ	Female	All	−1.054	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TWSG1–HNSC

Open the HNSC breakdown →