TWSG1

Across TCGA patient cohorts, TWSG1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWSG1-associated genes across cancer lineages are Rab25, Cyclin-E2, and A-Raf_pS299. Each is linked with TWSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWSG1-to-partner and partner-to-TWSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by TWSG1-low versus TWSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWSG1→partner) and Y-score (partner→TWSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.682	-3.321	<.001	.010	3	2
UCEC	Cyclin-E2 →	+0.226	+3.331	.005	.005	3	2
UCEC	A-Raf_pS299 →	-0.155	-2.999	.007	.035	3	1
UCEC	FoxM1 →	+0.250	+3.009	.045	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.172	-3.312	.004	.010	3	1
UCEC	GSK-3_pS9 →	-0.486	-2.321	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rab25 by TWSG1 expression — UCEC

Explore this box plot interactively →