TWNK

Across TCGA patient cohorts, TWNK protein abundance is significantly associated with the RNA expression of many other genes, with 12,838 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TWNK-associated genes across cancer lineages are TMED8, TTC8, and VEGFC. Each is linked with TWNK in more than 2 cancer types. Because this analysis shows association rather than direction, both TWNK-to-partner and partner-to-TWNK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TWNK versus TMED8 in BRCA, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWNK→partner) and Y-score (partner→TWNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMED8 →	-0.567	-0.331	<.001	<.001	3	3
BRCA	TTC8 →	-0.667	-0.269	<.001	<.001	3	3
OV	VEGFC →	-0.743	-0.344	.003	.004	3	2
OV	IFITM2 →	-0.884	-0.314	<.001	.009	3	2
OV	SPRY4 →	-0.946	-0.403	.005	<.001	3	2
OV	OTUB2 →	-0.565	-0.435	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,838 associations by consensus.

TWNK vs TMED8 — BRCA

Explore this scatter interactively →