TWNK

Across TCGA pan-cancer cohorts, TWNK RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TWNK data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TWNK RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TWNK expression acts as an unfavorable survival marker, although some lineages such as UVM and SCLC show a favorable association.

ACC, UVM, and LIHC are the cancer types where TWNK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.185	0.695	<.001	90	view →
UVM	DFS	Median	All	0.783	0.417	<.001	86	view →
LIHC	DFS	Tertile	All	0.340	0.484	.001	74	view →
BLCA	DFS	Median	All	0.328	0.660	<.001	59	view →
SCLC	OS	Tertile	II,III,IV	0.847	0.489	<.001	58	view →
LGG	DFS	Median	All	0.799	0.671	<.001	49	view →
LUAD	DFS	Tertile	II,III,IV	0.579	0.831	.002	41	view →
BRCA	DFS	Median	III,IV	0.926	0.828	.003	29	view →
CESC	DFS	Quartile	IV	0.213	0.814	.013	26	view →
GBM	DFS	Median	All	0.399	0.185	.001	24	view →
READ	OS	Quartile	II,III,IV	0.974	0.841	.022	20	view →
PCPG	DFS	Median	All	0.816	0.941	.011	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TWNK–ACC (DFS)

Open the ACC breakdown →