TWNK

Across TCGA patient cohorts, TWNK mutation is significantly associated with the RNA expression of many other genes, with 3,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWNK-associated genes across cancer lineages are MTND2P25, RNA5SP52, and HNRNPH1P2. Each is linked with TWNK in more than 1 cancer types. Because this analysis shows association rather than direction, both TWNK-to-partner and partner-to-TWNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P25 grouped by TWNK-low versus TWNK-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWNK→partner) and Y-score (partner→TWNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND2P25 →	+0.050	+5.164	<.001	.002	3	2
BRCA	RNA5SP52 →	+0.347	+3.494	.001	.005	3	2
BRCA	HNRNPH1P2 →	+0.047	+4.685	<.001	<.001	3	2
BRCA	RNU7-12P →	+0.574	+3.726	<.001	.005	3	2
SKCM	NCLP1 →	+0.143	+3.404	<.001	.004	3	2
SKCM	RPL22P10 →	+0.176	+2.447	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,728 associations by consensus.

MTND2P25 by TWNK expression — CESC

Explore this box plot interactively →