TWNK

Across TCGA patient cohorts, TWNK mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWNK-associated genes across cancer lineages are INPP4B, ASNS, and ATM. Each is linked with TWNK in more than 2 cancer types. Because this analysis shows association rather than direction, both TWNK-to-partner and partner-to-TWNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TWNK-low versus TWNK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWNK→partner) and Y-score (partner→TWNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.255	-2.321	.035	.033	3	3
UCEC	ASNS →	+0.434	+1.807	.001	.025	3	2
UCEC	ATM →	-0.376	-1.415	.027	.046	3	2
UCEC	14-3-3_beta →	-0.102	-3.558	.006	.002	3	1
UCEC	EGFR_pY1068 →	-0.252	-2.222	.007	.010	3	1
UCEC	eIF4E →	+0.176	+1.765	.026	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

INPP4B by TWNK expression — UCEC

Explore this box plot interactively →