TWNK

Across TCGA cell cohorts, TWNK RNA expression is significantly associated with the go_rna of many other GO terms, with 5,257 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TWNK-associated GO terms across cancer lineages are rRNA metabolic process, Ribosome biogenesis, and Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with TWNK in more than 18 cancer types. Because this analysis shows association rather than direction, both TWNK-to-partner and partner-to-TWNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA metabolic process grouped by TWNK-low versus TWNK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TWNK→partner) and Y-score (partner→TWNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	rRNA metabolic process →	+0.158	+1.288	<.001	<.001	3	19
BONE	Ribosome biogenesis →	+0.159	+1.387	<.001	<.001	3	19
LIVER	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.129	+0.926	<.001	<.001	3	19
LUNG_SCLC	Maturation of SSU-rRNA →	+0.150	+1.020	<.001	<.001	3	18
BONE	Ribosomal small subunit biogenesis →	+0.151	+1.151	<.001	<.001	3	18
BONE	rRNA processing →	+0.167	+1.158	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,257 associations by consensus.

rRNA metabolic process by TWNK expression — BONE

Explore this box plot interactively →