TWNK

Across TCGA cell cohorts, TWNK mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TWNK-associated genes across cancer lineages are OR8B12, SPDYE4, and OR8A1. Each is linked with TWNK in more than 1 cancer types. Because this analysis shows association rather than direction, both TWNK-to-partner and partner-to-TWNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by TWNK-low versus TWNK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWNK→partner) and Y-score (partner→TWNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B12 →	+0.054	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPDYE4 →	+0.037	+4.544	.003	.003	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.447	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.119	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR8B3 →	+0.036	+4.371	.002	.005	3	1
LUNG_NSCLC_LUAD	OR8B2 →	+0.087	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR8B12 by TWNK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →