TWF2

Across TCGA patient cohorts, TWF2 mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TWF2-associated genes across cancer lineages are MIR1238, MIR6072, and H3P46. Each is linked with TWF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TWF2-to-partner and partner-to-TWF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1238 grouped by TWF2-low versus TWF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TWF2→partner) and Y-score (partner→TWF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1238 →	+0.476	+3.304	<.001	.002	3	2
BRCA	MIR6072 →	+0.319	+9.057	<.001	.003	3	1
BRCA	H3P46 →	+0.088	+7.731	<.001	.009	3	1
BRCA	RNU1-49P →	+0.159	+8.471	<.001	.005	3	1
BRCA	RNU6-290P →	+0.402	+7.731	<.001	.009	3	1
BRCA	RNU4-45P →	+0.178	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

MIR1238 by TWF2 expression — UCEC

Explore this box plot interactively →