TWF1

Across TCGA pan-cancer cohorts, TWF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TWF1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TWF1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TWF1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where TWF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.569	0.896	<.001	24	view →
PDAC	DFS	Tertile	All	0.900	0.757	.008	7	view →
HNSC	DFS	Quartile	III,IV	0.937	0.705	.018	4	view →
UCEC	DFS	Median	II,III,IV	0.870	0.546	.047	4	view →
GBM	DFS	Median	All	0.273	0.457	.012	3	view →
LSCC	DFS	Quartile	All	1.000	0.893	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TWF1–LUAD (OS)

Open the LUAD breakdown →