TVP23C

Across TCGA patient cohorts, TVP23C mutation is significantly associated with the RNA expression of many other genes, with 1,695 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TVP23C-associated genes across cancer lineages are DOC2B, CYFIP1, and RNA5SP414. Each is linked with TVP23C in more than 1 cancer types. Because this analysis shows association rather than direction, both TVP23C-to-partner and partner-to-TVP23C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOC2B grouped by TVP23C-low versus TVP23C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TVP23C→partner) and Y-score (partner→TVP23C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOC2B →	-1.533	-3.700	<.001	.001	3	1
UCEC	CYFIP1 →	+0.558	+3.345	.007	.005	3	1
UCEC	RNA5SP414 →	+0.754	+2.840	<.001	<.001	3	1
UCEC	MIR7702 →	+0.263	+4.475	<.001	.003	3	1
UCEC	ZNF280B →	+0.598	+2.595	.002	.006	3	1
UCEC	MIR6793 →	+0.594	+2.706	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,695 associations by consensus.

DOC2B by TVP23C expression — UCEC

Explore this box plot interactively →