TVP23C

Across TCGA pan-cancer cohorts, TVP23C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TVP23C data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TVP23C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TVP23C expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

ACC, BRCA, and LGG are the cancer types where TVP23C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.199	0.710	<.001	93	view →
BRCA	OS	Quartile	II,III,IV	0.628	0.454	.002	55	view →
LGG	DFS	Median	All	0.639	0.819	<.001	53	view →
BLCA	OS	Quartile	III,IV	0.446	0.833	.001	38	view →
LUSC	DFS	Quartile	III,IV	0.138	0.897	.001	37	view →
PAAD	DFS	Quartile	All	0.477	0.169	<.001	37	view →
LUAD	OS	Median	III,IV	0.525	0.178	.001	26	view →
KIRP	OS	Tertile	III,IV	0.251	0.855	.014	24	view →
KIRC	DFS	Median	II,III,IV	0.449	0.593	.012	21	view →
GBM	DFS	Quartile	All	0.200	0.360	.005	20	view →
LAML	DFS	Median	All	0.489	0.271	.008	20	view →
CESC	OS	Tertile	All	0.871	0.742	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TVP23C–ACC (DFS)

Open the ACC breakdown →