TVP23C

Across TCGA patient cohorts, TVP23C mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TVP23C-associated genes across cancer lineages are EGFR, FoxM1, and JNK_pT183_Y185. Each is linked with TVP23C in more than 1 cancer types. Because this analysis shows association rather than direction, both TVP23C-to-partner and partner-to-TVP23C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by TVP23C-low versus TVP23C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TVP23C→partner) and Y-score (partner→TVP23C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.370	-3.169	<.001	.020	3	1
UCEC	FoxM1 →	+0.337	+3.169	.017	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.248	-3.156	.007	.020	3	1
UCEC	PDCD4 →	-0.721	-3.169	.005	.020	3	1
UCEC	Annexin-1 →	+0.925	+2.827	.001	.035	3	1
UCEC	Smad3 →	+0.173	+3.169	.037	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR by TVP23C expression — UCEC

Explore this box plot interactively →