TUT7

Across TCGA cell cohorts, TUT7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,764 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TUT7-associated GO terms across cancer lineages are Transposable element silencing by mRNA destabilization, Polyuridylation-dependent mRNA catabolic process, and Macroautophagy. Each is linked with TUT7 in more than 17 cancer types. Because this analysis shows association rather than direction, both TUT7-to-partner and partner-to-TUT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transposable element silencing by mRNA destabilization grouped by TUT7-low versus TUT7-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TUT7→partner) and Y-score (partner→TUT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Transposable element silencing by mRNA destabilization →	+0.171	+0.855	<.001	<.001	3	18
BONE	Polyuridylation-dependent mRNA catabolic process →	+0.102	+0.716	<.001	.004	3	18
OESOPHAGUS	Macroautophagy →	+0.064	+0.748	.002	.002	3	14
OESOPHAGUS	Process utilizing autophagic mechanism →	+0.065	+0.679	.002	.005	3	14
OESOPHAGUS	Autophagy →	+0.065	+0.679	.002	.005	3	14
PANCREAS	Positive regulation of hydrolase activity →	+0.062	+0.736	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

Transposable element silencing by mRNA destabilization by TUT7 expression — BREAST

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