TUBE1

Across TCGA patient cohorts, TUBE1 mutation is significantly associated with the RNA expression of many other genes, with 900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBE1-associated genes across cancer lineages are SEPTIN7P5, RNU6-633P, and EZH2P1. Each is linked with TUBE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBE1-to-partner and partner-to-TUBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN7P5 grouped by TUBE1-low versus TUBE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBE1→partner) and Y-score (partner→TUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SEPTIN7P5 →	+0.066	+4.199	<.001	.009	3	2
SKCM	RNU6-633P →	+0.334	+4.867	<.001	<.001	3	2
BRCA	EZH2P1 →	+0.188	+3.692	<.001	.009	3	2
BRCA	IGHVIII-67-3 →	+0.254	+5.453	<.001	.002	3	2
BRCA	CYP4F10P →	+0.098	+5.054	.008	.003	3	2
UCEC	RPARP-AS1 →	+0.490	+2.743	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 900 associations by consensus.

SEPTIN7P5 by TUBE1 expression — SKCM

Explore this box plot interactively →