Across TCGA pan-cancer cohorts, TUBBP2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TUBBP2’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TUBBP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUBBP2 is over-expressed in tumor.
HNSC, LUSC, and KIRP are the cancer types where TUBBP2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBBP2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.