TUBBP1

Across TCGA patient cohorts, TUBBP1 mutation is significantly associated with the RNA expression of many other genes, with 2,272 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBBP1-associated genes across cancer lineages are RNU6ATAC8P, RN7SKP295, and TSSC4. Each is linked with TUBBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBBP1-to-partner and partner-to-TUBBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC8P grouped by TUBBP1-low versus TUBBP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBBP1→partner) and Y-score (partner→TUBBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6ATAC8P →	+0.332	+3.376	<.001	.007	3	2
CESC	RN7SKP295 →	+0.117	+4.144	<.001	.009	3	2
SKCM	TSSC4 →	+0.462	+3.436	.003	.003	3	2
UCEC	MIR4449 →	+0.417	+1.654	.002	.005	3	2
UCEC	TANGO2 →	+0.319	+2.885	.007	<.001	3	2
UCEC	RPL23AP82 →	+0.464	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,272 associations by consensus.

RNU6ATAC8P by TUBBP1 expression — CESC

Explore this box plot interactively →