Across TCGA pan-cancer cohorts, TUBB8P8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TUBB8P8’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TUBB8P8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TUBB8P8 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
HNSC, PAAD, and BRCA are the cancer types where TUBB8P8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB8P8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.