Across TCGA patient cohorts, TUBB4B mutation is significantly associated with the RNA expression of many other genes, with 962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB4B-associated genes across cancer lineages are APOBEC3AP1, MRPS16P3, and IGHD4-4. Each is linked with TUBB4B in more than 3 cancer types. Because this analysis shows association rather than direction, both TUBB4B-to-partner and partner-to-TUBB4B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB4B→partner) and Y-score (partner→TUBB4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APOBEC3AP1 →	+0.278	+5.505	<.001	.004	3	4
HNSC	MRPS16P3 →	+0.112	+5.578	<.001	.004	3	3
UCEC	IGHD4-4 →	+0.482	+3.003	<.001	.007	3	3
SKCM	MIR517B →	+0.412	+5.900	<.001	<.001	3	3
CESC	MIR7-3 →	+0.282	+5.342	<.001	.002	3	2
HNSC	MIR301B →	+0.604	+5.241	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 962 associations by consensus.

Exploration

TUBB4B survival (RNA) · tumor vs normal (RNA) · all TUBB4B data types