TUBB2B

Across TCGA pan-cancer cohorts, TUBB2B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TUBB2B’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TUBB2B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TUBB2B is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where TUBB2B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB2B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−2.611	<.001	12	view →
HNSC	Male	All	−1.620	<.001	12	view →
COAD	Female	III,IV	−1.910	<.001	11	view →
PDAC	Female	II,III,IV	−1.326	<.001	8	view →
LUAD	All	All	+0.579	.009	5	view →
LSCC	Male	All	+0.881	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TUBB2B–CCRCC

Open the CCRCC breakdown →