TUBB2B

Across TCGA pan-cancer cohorts, TUBB2B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TUBB2B data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TUBB2B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB2B expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

MESO, UCEC, and ACC are the cancer types where TUBB2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.270	0.502	<.001	108	view →
UCEC	DFS	Median	All	0.613	0.690	.002	68	view →
ACC	OS	Tertile	All	0.383	0.914	<.001	62	view →
THCA	OS	Median	All	0.892	0.989	.002	58	view →
STAD	OS	Tertile	All	0.643	0.757	.014	47	view →
BLCA	DFS	Quartile	All	0.474	0.626	.003	42	view →
COAD	DFS	Quartile	All	0.334	0.629	.001	39	view →
LGG	DFS	Tertile	All	0.643	0.821	<.001	35	view →
HNSC	OS	Median	III,IV	0.409	0.220	.009	25	view →
BRCA	DFS	Tertile	All	0.589	0.468	.003	23	view →
UVM	OS	Quartile	II,III,IV	0.724	0.937	.011	22	view →
PAAD	DFS	Quartile	II,III,IV	0.514	0.296	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TUBB2B–MESO (OS)

Open the MESO breakdown →