TUBB2B

Across TCGA patient cohorts, TUBB2B mutation is significantly associated with the RNA expression of many other genes, with 1,080 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB2B-associated genes across cancer lineages are ZYXP1, ZBED1P1, and RNU6-740P. Each is linked with TUBB2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB2B-to-partner and partner-to-TUBB2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZYXP1 grouped by TUBB2B-low versus TUBB2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB2B→partner) and Y-score (partner→TUBB2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZYXP1 →	+0.144	+3.374	<.001	.003	3	2
BLCA	ZBED1P1 →	+0.090	+3.937	<.001	.007	3	2
STAD	RNU6-740P →	+0.237	+4.597	<.001	.005	3	2
COAD	RNU6-1064P →	+0.339	+3.736	.002	.005	3	2
COAD	AGBL4-IT1 →	+0.440	+4.366	<.001	<.001	3	2
BLCA	RNMTL1P2 →	+0.044	+5.229	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,080 associations by consensus.

ZYXP1 by TUBB2B expression — UCEC

Explore this box plot interactively →