TUBB2B

Across TCGA patient cohorts, TUBB2B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB2B-associated genes across cancer lineages are FOXO3a_pS318_S321, PDCD4, and PDK1. Each is linked with TUBB2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB2B-to-partner and partner-to-TUBB2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TUBB2B-low versus TUBB2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB2B→partner) and Y-score (partner→TUBB2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.146	-3.312	.007	.010	3	1
UCEC	PDCD4 →	-0.677	-2.575	<.001	.010	3	1
UCEC	PDK1 →	+0.102	+3.013	.030	.018	3	1
UCEC	Stathmin →	+0.140	+2.115	.020	.019	3	1
UCEC	TIGAR →	+0.144	+2.321	.030	.034	3	1
UCEC	Chk1_pS345 →	-0.132	-2.794	.028	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by TUBB2B expression — UCEC

Explore this box plot interactively →