TUBB2B

Across TCGA cell cohorts, TUBB2B mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TUBB2B-associated genes across cancer lineages are KIR2DL3, ARMH2, and TCP11X1. Each is linked with TUBB2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB2B-to-partner and partner-to-TUBB2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR2DL3 grouped by TUBB2B-low versus TUBB2B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB2B→partner) and Y-score (partner→TUBB2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
SKIN	ARMH2 →	+0.026	+5.415	<.001	.004	3	1
SKIN	TCP11X1 →	+0.013	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KIR2DL3 by TUBB2B expression — SKIN

Explore this box plot interactively →