TUBB2A

Across TCGA pan-cancer cohorts, TUBB2A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TUBB2A data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TUBB2A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TUBB2A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and LUSC are the cancer types where TUBB2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.064	0.924	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.629	.024	22	view →
LUSC	OS	Median	All	0.203	0.676	.007	21	view →
LIHC	DFS	Median	All	0.096	0.526	.023	6	view →
BLCA	DFS	Median	III,IV	0.139	0.572	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TUBB2A–BRCA (OS)

Open the BRCA breakdown →