TUBB2A

Across TCGA pan-cancer cohorts, TUBB2A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TUBB2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TUBB2A RNA is repressed in tumor relative to normal tissue. In most cancer types TUBB2A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, LUAD, and LIHC are the cancer types where TUBB2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.993	<.001	10	view →
LUAD	All	II,III,IV	+0.970	<.001	10	view →
LIHC	All	III,IV	+1.373	<.001	9	view →
KICH	All	II,III,IV	−1.096	<.001	8	view →
LUSC	Male	All	+0.910	<.001	7	view →
UCEC	All	III,IV	−1.981	<.001	6	view →
BRCA	All	II,III,IV	−0.981	<.001	6	view →
THCA	Female	All	−0.833	<.001	6	view →
READ	Female	All	−2.071	<.001	5	view →
BLCA	Female	III,IV	−1.371	.011	5	view →
COAD	All	II,III,IV	−0.572	.001	5	view →
PRAD	All	All	+1.132	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TUBB2A–KIRC

Open the KIRC breakdown →