TUBB2A

Across TCGA pan-cancer cohorts, TUBB2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TUBB2A data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TUBB2A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBB2A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where TUBB2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.914	1.000	.005	12	view →
CCRCC	OS	Tertile	All	0.761	0.938	.006	9	view →
HNSC	DFS	Median	III,IV	0.916	0.700	.014	5	view →
UCEC	DFS	Median	All	0.963	0.844	.004	4	view →
PDAC	OS	Median	III,IV	0.782	0.381	.011	4	view →
LSCC	DFS	Median	All	0.498	0.828	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TUBB2A–LUAD (DFS)

Open the LUAD breakdown →