TUBB2A

Across TCGA patient cohorts, TUBB2A mutation is significantly associated with the RNA expression of many other genes, with 1,278 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB2A-associated genes across cancer lineages are RN7SKP100, RNU6-275P, and RNA5SP415. Each is linked with TUBB2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB2A-to-partner and partner-to-TUBB2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP100 grouped by TUBB2A-low versus TUBB2A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB2A→partner) and Y-score (partner→TUBB2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP100 →	+0.102	+4.985	<.001	.002	3	2
SKCM	RNU6-275P →	+0.551	+6.624	<.001	.001	3	2
UCEC	RNA5SP415 →	+0.413	+2.488	.003	.001	3	2
COAD	RNA5SP378 →	+1.016	+4.081	<.001	.004	3	2
UCEC	BTBD10 →	+0.521	+3.491	.002	.002	3	1
UCEC	LIN7C →	+0.567	+2.708	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,278 associations by consensus.

RN7SKP100 by TUBB2A expression — BLCA

Explore this box plot interactively →