TUBB2A

Across TCGA patient cohorts, TUBB2A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB2A-associated genes across cancer lineages are 14-3-3_beta, GATA6, and Notch1. Each is linked with TUBB2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB2A-to-partner and partner-to-TUBB2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TUBB2A-low versus TUBB2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB2A→partner) and Y-score (partner→TUBB2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.119	-2.893	.005	.001	3	1
UCEC	GATA6 →	-0.182	-1.693	.005	.044	3	1
UCEC	Notch1 →	+0.138	+2.222	.021	.011	3	1
UCEC	p62 Lck ligand →	+0.302	+3.169	.029	.018	3	1
UCEC	PCNA →	+0.201	+2.222	.028	.011	3	1
UCEC	S6_pS240_S244 →	+0.529	+2.222	.002	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by TUBB2A expression — UCEC

Explore this box plot interactively →