Across TCGA patient cohorts, TUBB protein abundance is significantly associated with the RNA expression of many other genes, with 13,225 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TUBB-associated genes across cancer lineages are ADGRE3, TNFRSF10C, and CXCR2. Each is linked with TUBB in more than 5 cancer types. Because this analysis shows association rather than direction, both TUBB-to-partner and partner-to-TUBB results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB→partner) and Y-score (partner→TUBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE3 →	-0.706	-0.362	<.001	<.001	3	6
UCEC	TNFRSF10C →	-1.003	-0.356	.001	.005	3	6
HNSC	CXCR2 →	-1.049	-0.539	<.001	.001	3	6
OV	KIFC1 →	+1.131	+0.442	<.001	<.001	3	6
OV	TPX2 →	+1.167	+0.478	<.001	<.001	3	6
UCEC	VNN3 →	-0.908	-0.367	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,225 associations by consensus.

Exploration

TUBB survival (RNA) · tumor vs normal (RNA) · all TUBB data types