Across TCGA pan-cancer cohorts, TUBB RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TUBB data layer compared with 2 for mutation status and 6 for mass-spec protein.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TUBB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBB expression acts as an unfavorable survival marker, although some lineages such as READ and ESCA show a favorable association.
KIRP, KICH, and ACC are the cancer types where TUBB RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.